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Events
March - With the death of Ferdinand II of Aragon, his grandson Charles of Ghent becomes King of Spain as Carlos I.
July - Selim I of the Ottoman Empire declares war on the Mameluks and invades Syria.
August 13 - Treaty of Noyon - Peace between France and Spain. Francis recognizes Charles's claim to Naples, and Charles recognizes Francis's claim to Milan.
August 24 - Battle of Merj-Dabik. The Ottomans defeat the Mameluks, who abandon Syria.
October 28 - Battle of Yaunis Khan. Turkish forces under the Grand Vizier Sinan Pasha defeat the Mameluks near Gaza.
December 4 - Treaty of Brussels - Peace between France and the Empire.
Pedro de Solis discovers the La Plata River.
Literature
Thomas More - Utopia.
Ludovico Ariosto - Orlando Furioso.
Births
February 18 - Queen Mary I of England (died 1558).
Deaths
23 January - Ferdinand II of Aragon.
13 December - Johannes Trithemius, scholar and cryptographer.
Category:1516
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